I-Revolutionary Study Yembula Iqhaza Le-Pirin Protein ku-Quercetin Metabolism, Ukuchaza Kabusha Izindlela Zokubonakaliswa Kweselula
Agasti 11, 2025 - Ucwaningo oluphawulekayo olushicilelwe ku-Molecular Pharmacology luguqule amashumi eminyaka esivumelwano sesayensi ngokudalula ukuthi iphrotheni i-Pirin ayilawuli indlela yokusayina ye-NF-κB njengoba bekukholelwa ngaphambilini. Esikhundleni salokho, abacwaningi bathola ukuthi i-Pirin isebenza njenge-quercetinase—i-enzyme egaya i-quercetin ye-flavonoid—okutholakele okungalungisa kabusha ukuqonda kwethu ukuvuvukala, umdlavuza, nokulawulwa kwe-metabolic.
Ukutholakala Okungalindelekile
Kwaphela iminyaka, u-Pirin wayecatshangwa ukuthi ungumxhumanisi wendlela ye-NF-κB, umlawuli obalulekile wezimpendulo zamasosha omzimba nokuvuvukala. Kodwa-ke, ithimba labacwaningi eliholwa nguDkt Meschkewitz e-Michigan State University alitholanga ubufakazi bokuthi i-Pirin ibophezela ku-p65 (i-NF-κB subunit eyisihluthulelo), naphezu kwemizamo eminingi yokusebenzisa i-surface plasmon resonance (SPR), i-chromatography ye-size-exclusion (SEC), kanye nokuhlolwa kwe-fluorescence polarization (FP).
Esikhundleni salokho, ucwaningo lwembula ukuthi i-Pirin ngokuyinhloko itholakala ku-endoplasmic reticulum (ER), lapho yehlisa khona i-quercetin-i-antioxidant enamandla etholakala ekudleni okufana nama-apula, u-anyanisi, namajikijolo. Ithimba lihlonze i-CCG-257081, inhibitor encane ye-molecule evimbela ngokuncintisana umsebenzi we-quercetinase we-Pirin, okuholela ekwandeni okuphawulekayo kwamazinga e-quercetin e-intracellular.
Imithelela Yezempilo Nezifo
I-Quercetin sekuyisikhathi eside icwaningwa ngezindawo zayo zokulwa nokuvuvukala, i-antioxidant, kanye nezindawo ezingaba khona zokulwa nomdlavuza. Lokhu kutholakala kuphakamisa ukuthi i-Pirin ingase ibambe iqhaza elibalulekile ekuguquleni i-quercetin's bioavailability kumaseli, okungaba nomthelela ezimweni ezinjengokuvuvukala okungapheli, i-neurodegeneration, kanye nokuqhubeka komdlavuza.
"Lokhu kutholakala kusiphoqa ukuthi siphinde sicabangele ukuthi i-quercetin ilawulwa kanjani emzimbeni," kusho uDkt. Lisabeth, umbhali ohlangene wocwaningo. "Uma i-Pirin ilawula ukuwohloka kwe-quercetin, ukuvimbela i-Pirin kungathuthukisa imiphumela yokwelapha ye-quercetin-into manje esiyihlola kumamodeli angaphambi komtholampilo."
Ubani okufanele agweme i-quercetin?
Imithamo ephezulu kakhulu ye-quercetin ingalimaza izinso. Kufanele uthathe ikhefu ngezikhathi ezithile ekuthatheni i-quercetin. Abesifazane abakhulelwe, abancelisayo, kanye nabantu abanesifo sezinso kufanele bagweme i-quercetin. Ngemithamo engaphezu kuka-1 g ngosuku, kube nemibiko yokulimala ezinso.
Ngingakwazi ukuthatha i-quercetin novithamini D ndawonye?
Yebo, i-quercetin ne-vitamin D ngokuvamile ingathathwa ndawonye. Eqinisweni, ezinye izifundo ziphakamisa ukuthi zingase zisebenze ngokubambisana ukuze zisekele impilo yokuzivikela komzimba. I-Quercetin, i-flavonoid etholakala ezithelweni nasemifino eminingi, kanye ne-vitamin D, isakhi esisekela umsebenzi wokuzivikela omzimba kanye nempilo yamaselula, ingatholakala ekuhlanganiseni izithako.
Yini okufanele uyigweme lapho uthatha i-quercetin?
Qaphela uma uthatha izidakamizwa ezinjengama-antibiotics, i-cyclosporine, i-warfarin, noma izidakamizwa ezishintshwa yisibindi. I-Quercetin ingase iguqule ukuthi le mithi isebenza kanjani futhi ikhulise ingozi yemiphumela emibi. Akubonakali kukhona ukusebenzisana phakathi kwe-quercetin nokudla noma amanye amakhambi nezithako.
Ingabe i-quercetin iphephile ezinganeni?
Nakuba i-quercetin itholakala ngokwemvelo ekudleni okuningi futhi ngokuvamile ibhekwa njengephephile kubantu abadala ngamanani alinganiselwe, kukhona ucwaningo olulinganiselwe mayelana nokuphepha nokusebenza kwayo ezinganeni, futhi kuyalulekwa ukuqapha.
Uyithatha nini i-quercetin?
Ungathatha i-quercetin nganoma yisiphi isikhathi sosuku. Kodwa-ke, kufanele ucabange ukuyiphuza ngezikhathi zokudla ngoba ukudla okuqukethe uvithamini C, i-bromelain, namafutha anempilo kungasiza ukumuncwa kwayo. Ngaphezu kwalokho, “abanye abantu bangase bakhethe ukuyidla kanye nokudla ukuze banciphise ubuhlungu obungase bube khona emathunjini,” kusho uDkt. Ormond.