Uphononongo loguquko lutyhila indima yeProtein yePirin kwi-Quercetin Metabolism, Ukuchaza kwakhona iindlela zokuSayina zeSelula
Ngo-Agasti 11, 2025 - Uphononongo oluphawulekayo olupapashwe kwi-Molecular Pharmacology luye lwabhukuqa amashumi eminyaka emvumelwano yesayensi ngokutyhila ukuba iprotheni iPirin ayilawuli indlela yokubonisa i-NF-κB njengoko kwakukholelwa ngaphambili. Endaweni yoko, abaphandi bafumanisa ukuba i-Pirin isebenza njenge-quercetinase-i-enzyme eyenza i-quercetin ye-flavonoid-isiphumo esinokuthi sihlaziye ukuqonda kwethu ukudumba, umhlaza kunye nokulawulwa kwe-metabolic.
UkuFumana okungalindelekanga
Kwiminyaka, uPirin wayecatshangelwa ukuba yi-co-activator ye-NF-κB indlela, umlawuli obalulekileyo weempendulo ze-immune kunye nokuvuvukala. Nangona kunjalo, iqela lophando elikhokelwa nguDkt Meschkewitz kwiYunivesithi yaseMichigan State alifumananga ubungqina bePirin ebophelelayo kwi-p65 (i-NF-κB engundoqo ye-subunit), nangona iinzame ezininzi zisebenzisa i-surface plasmon resonance (SPR), i-chromatography yobungakanani (i-SEC), kunye ne-fluorescence polarization (FP) assays.
Kunoko, uphando lubonise ukuba i-Pirin ngokuyinhloko ifakwe kwi-endoplasmic reticulum (ER), apho iyancipha i-quercetin-i-antioxidant enamandla efumaneka kukutya okufana ne-apula, i-anyanisi kunye namajikijolo. Iqela lichonge i-CCG-257081, i-inhibitor encinci ye-molecule ekhuphisanayo ivimbela umsebenzi we-quercetinase wePirin, ekhokelela ekunyuseni okukhulu kumanqanaba e-quercetin ye-intracellular.
Iimpembelelo kwiMpilo kunye neZifo
I-Quercetin kudala ifundwe ngenxa yokuchasana nokudumba, i-antioxidant, kunye neempawu zokulwa nomhlaza. Oku kufunyaniswayo kucebisa ukuba iPirin inokudlala indima ebalulekileyo ekumodareyitheni i-bioavailability ye-quercetin kwiiseli, ezinokuphembelela iimeko ezifana nokudumba okungapheliyo, i-neurodegeneration, kunye nokuqhubeka komhlaza.
"Oku kufunyaniswa kusishukumisela ukuba siphinde sihlolisise indlela i-quercetin elawulwa ngayo emzimbeni," kusho uDkt. "Ukuba i-Pirin ilawula ukuthotywa kwe-quercetin, ukuvimbela i-Pirin kunokuphucula iziphumo zonyango ze-quercetin-into ngoku siyihlola kwiimodeli zangaphambili."
Ngubani omele ayiphephe i-quercetin?
Amanani aphezulu kakhulu e-quercetin angonakalisa izintso. Kuya kufuneka uthathe ikhefu lokuthatha i-quercetin. Abasetyhini abakhulelweyo, abafazi abancancisayo, kunye nabantu abanesifo sezintso kufuneka baphephe i-quercetin. Kwiidosi ezingaphezu kwe-1 g ngosuku, kukho iingxelo zomonakalo kwizintso.
Ndingayithatha iquercetin kunye nevithamin D kunye?
Ewe, i-quercetin kunye nevithamin D zinokuthathwa kunye. Ngapha koko, ezinye izifundo zibonisa ukuba banokusebenza ngokubambisana ukuxhasa impilo yomzimba. I-Quercetin, i-flavonoid efumaneka kwiziqhamo ezininzi kunye nemifuno, kunye ne-vitamin D, isondlo esixhasa umsebenzi wokuzivikela omzimba kunye nempilo yeselula, inokufumaneka kwizongezelelo ezidibeneyo.
Yintoni omele uyiphephe xa uthatha i-quercetin?
Qaphela ukuba uthatha iziyobisi ezifana ne-antibiotics, i-cyclosporine, i-warfarin, okanye iziyobisi ezitshintshwa yisibindi. I-Quercetin inokutshintsha indlela la mayeza asebenza ngayo kwaye aphakamise umngcipheko wemiphumo emibi. Akubonakali ngathi kukho ukusebenzisana phakathi kwe-quercetin kunye nokutya okanye ezinye imifuno kunye nezongezelelo.
Ngaba i-quercetin ikhuselekile kubantwana?
Nangona i-quercetin ifumaneka ngokwemvelo kukutya okuninzi kwaye ngokuqhelekileyo ithathwa njengekhuselekile kubantu abadala kwimilinganiselo ephakathi, kukho uphando oluncinci malunga nokhuseleko kunye nokusebenza kakuhle kwabantwana, kwaye isilumkiso siyacetyiswa.
Uyithatha nini iquercetin?
Ungathatha i-quercetin nangaliphi na ixesha losuku. Nangona kunjalo, kufuneka ucinge ngokuyithatha ngexesha lokutya kuba ukutya okunevithamin C, i-bromelain, kunye namafutha anempilo kunokuncedisa ukufunxa kwayo. Ukongezelela, uGqr. Ormond uthi, “abanye abantu basenokukhetha ukuyisela kunye nokutya ukuze banciphise ukungonwabi kwesisu.