Urolithin umgubo

Urolithin A yi i-metabolite ikhompawundi evela kwinguqu ye i-ellagitannins ngebhaktheriya yamathumbu. Urolithin ecocekileyo a umgubo ungoweklasi yeekhompawundi eziphilayo ezaziwa ngokuba yibenzo-iicoumarins okanye dibenzo-α-iipyrones. Izandulela zayo - i-elagic acids kunye ne-ellagitannins - zikho kuyo yonke indawo kwindalo, kuquka izityalo ezidliwayo, ezifana iirharnati, amaqunube, amaqunube, walnuts, kunye nabanye.(1)

Ziziphi iingenelo ze-Urolithin A?
Izilingo zeklinikhi zibonisa ukuba kwandisa amandla emisipha kunye nokunciphisa ukuvutha. Amanqaku aphambili: I-500 mg okanye i-1000 mg inyusa amandla emisipha. I-1000 mg iphucula ukunyamezela kwemisipha kunye nokunciphisa ukuvuvukala.

Inokunciphisa imiphumo ye-senescence, kuquka leyo ebangelwa yimitha ye-UVA, eyona nto ingunobangela wokuguga kolusu kunye negalelo kulo lonke uhlobo lomhlaza wolusu. Uphando olongezelelweyo lubonisa ukuba kunokusebenza ngokunyusa ukususwa kwe-mitochondria eyonakalisiweyo (mitophagy) kunye nokuphucula impilo ye-mitochondrial. Oku kukhokelela ekunikeni amandla kwakhona iiseli ekunciphiseni ukuqhekeka kwe-collagen kunye nokwandisa impilo yolusu. Uphando olongezelelweyo luyafuneka, kodwa lubonisa amandla amaninzi ekubeni sisithako esichasene nokuguga ukubukela.

Ukubonakala kolutsha olungakumbi: Ekupheleni kwe-8-iveki ye-8 ye-randomized-controlled controlled placebo kunye ne-topical 1% ye-Urolithin A, izifundo ziqaphele ukuphuculwa okubonakalayo kwimbonakalo yemigca emihle kunye nemibimbi emva kweeveki ze-2 nje. Ngeeveki ezisi-8, kwakukho impembelelo ebalulekileyo kumthamo wokushwabana nobunzulu.(2)

Ngaba ichasene nokuguga?
I-Urolithin, i-intestinal microbiota metabolites yokutya okutyebileyo kwe-ellagitannin, ibonisa imisebenzi yokulwa nokuguga. Iphezulu kakhulu kunezinye iintlobo ze-urolithin malunga noku anti-ukuguga umsebenzi.

Kuthatha ixesha elingakanani ukuba i-Urolithin A isebenze?
Nangona iziphumo zinokwahluka, abaninzi abantu bafumana ukuphuculwa kokunyamezela kwemisipha kunye namanqanaba amandla ngaphakathi kweeveki ze-4-8. Iinzuzo zexesha elide kwimpilo ye-metabolic kunye nokuguga zivela emva kweeveki ezili-12 zokusetyenziswa rhoqo.

Ngaba i-Urolithin ingcono kune-NMN?
I-Urolithin A inokufaneleka ukuba unomdla kwimpilo yeselula, kanti NMN kunokuba ngcono ukunyusa imetabolism kunye namanqanaba amandla.