Diaminopyoridina oxide wa tsitsi

Kodi diaminopyrimidine oxide ndi chiyani?
Unodial (dzina lamankhwala: diaminopyrimidine oxide) ndi mankhwala oletsa kutayika tsitsi omwe amachepetsa follicle fibrosis ya tsitsi poletsa lysyl hydroxylase mRNA mawu, kuyambitsa tsitsi la follicle vasodilation, ndikuteteza maselo a papilla kupsinjika kwa okosijeni komanso kukondoweza kwa androgen. Nthawi zambiri amapezeka muzamankhwala apamwamba oletsa kutayika tsitsi.
Kodi Pyrrolidinyl diaminopyrimidine okusayidi tsitsi kukula?
Diaminopyrimidine oxide imathandizira kufewetsa kolajeni ndipo itha kugwiritsidwa ntchito muzopangira zosamalira tsitsi pochiza tsitsi lomwe limayamba chifukwa cha kutayika kwatsitsi msanga. Imalepheretsa ntchito ya lysine hydroxylase ndikuletsa fibrosis. Lysine hydroxylase hydroxylates lysine m'chigawo cha telopeptide cha collagen, kupangitsa mamolekyu a collagen kukhala ovuta kusokoneza ndikupangitsa kuti aunjike. Kuchulukana kwa collagen kumabweretsa kuumitsa ndi kufota kwa ma follicle atsitsi ozungulira, zomwe zimapangitsa fibrosis ndikuchepetsa kukula kwa tsitsi. Imalepheretsanso ntchito ya 5α-reductase, motero imachepetsa kutembenuka kwa testosterone kukhala dihydrotestosterone. Ndizoyenera kugwiritsidwa ntchito mumafuta atsitsi, zowongolera, zotsitsimutsa tsitsi, ma shampoos, zopopera tsitsi, komanso pochiza kutayika tsitsi kwanyengo.