Hōʻike ʻo Revolutionary Study i ke kuleana o Pirin Protein i ka Quercetin Metabolism, ka wehewehe hou ʻana i nā ala hōʻailona kelepona.
ʻAukake 11, 2025 - Ua hoʻohuli ʻia kahi noiʻi ʻāina i paʻi ʻia ma Molecular Pharmacology i nā makahiki he ʻumi o ka ʻikepili ʻepekema ma ka hōʻike ʻana ʻaʻole hoʻoponopono ka protein Pirin i ke ala hōʻailona NF-κB e like me ka manaʻo mua. Akā, ua ʻike nā mea noiʻi e hana ana ʻo Pirin ma ke ʻano he quercetinase-he enzyme e hoʻoheheʻe i ka flavonoid quercetin-he ʻike e hiki ke hoʻololi i ko mākou ʻike no ka mumū, ka maʻi kanesa, a me ka hoʻoponopono metabolic.
ʻO ka ʻike i manaʻo ʻole ʻia
No nā makahiki, ua manaʻo ʻia ʻo Pirin he co-activator o ke ala NF-κB, he mea hoʻoponopono koʻikoʻi o nā pane a me ka mumū. Eia naʻe, ʻaʻole i loaʻa i kahi hui noiʻi i alakaʻi ʻia e Dr. Meschkewitz ma Michigan State University i kahi hōʻike o Pirin e hoʻopaʻa ana i ka p65 (kahi kī NF-κB subunit), ʻoiai nā hoʻāʻo he nui e hoʻohana i ka surface plasmon resonance (SPR), size-exclusion chromatography (SEC), a me ka fluorescence polarization (FP) assays.
Akā, ua hōʻike ʻia ka noiʻi ʻana ʻo Pirin i loko o ka endoplasmic reticulum (ER), kahi e hoʻohaʻahaʻa ai i ka quercetin-he antioxidant ikaika i loaʻa i nā meaʻai e like me nā ʻāpala, nā aniani, a me nā hua. Ua ʻike ka hui i ka CCG-257081, kahi mea hoʻopaneʻe liʻiliʻi-mole e hoʻokūkū i ka hana quercetinase a Pirin, e alakaʻi ana i ka piʻi nui o nā pae quercetin intracellular.
Nā hopena no ke olakino a me ka maʻi
Ua aʻo lōʻihi ʻia ʻo Quercetin no kāna mau anti-inflammatory, antioxidant, a me nā waiwai anticancer. Hōʻike kēia ʻike e hiki ke hana koʻikoʻi ʻo Pirin i ka hoʻololi ʻana i ka bioavailability o quercetin i loko o nā cell, hiki ke hoʻololi i nā kūlana e like me ka maʻi ʻeha mau, neurodegeneration, a me ka piʻi ʻana o ka maʻi kanesa.
"Ke koi nei kēia ʻike iā mākou e noʻonoʻo hou i ke ʻano o ka hoʻoponopono ʻana o ka quercetin i loko o ke kino," wahi a Dr. Lisabeth, kahi mea kākau o ka noiʻi. "Inā mālama ʻo Pirin i ka hoʻohaʻahaʻa ʻana i ka quercetin, a laila hiki i ka pale ʻana iā Pirin ke hoʻonui i nā hopena therapeutic o quercetin - kahi mea a mākou e ʻimi nei i nā hiʻohiʻona preclinical."
ʻO wai ka mea e pale aku i ka quercetin?
Hiki ke hōʻino ʻia nā puʻupaʻa i ka nui o ka quercetin. Pono ʻoe e hoʻomaha manawa mai ka lawe ʻana i ka quercetin. ʻO nā wahine hāpai, nā wahine hānai, a me nā poʻe me ka maʻi kīkī e pale aku i ka quercetin. I ka nui ma mua o 1 g i kēlā me kēia lā, ua hōʻike ʻia ka hōʻino ʻana i nā puʻupaʻa.
Hiki iaʻu ke lawe pū i ka quercetin a me ka vitamin D?
ʻAe, hiki ke lawe pū ʻia ka quercetin a me ka vitamin D. ʻO ka ʻoiaʻiʻo, ʻōlelo kekahi mau haʻawina e hana like paha lākou e kākoʻo i ke olakino immune. ʻO Quercetin, he flavonoid i loaʻa i loko o nā huaʻai a me nā mea kanu he nui, a me ka huaora D, kahi meaʻai e kākoʻo ana i ka hana immune a me ke olakino cellular, hiki ke loaʻa i nā mea hoʻohui hui.
He aha ka mea e pale aku ai i ka lawe ʻana i ka quercetin?
E makaʻala inā e lawe ana ʻoe i nā lāʻau lapaʻau e like me nā antibiotic, cyclosporine, warfarin, a i ʻole nā lāʻau lapaʻau i hoʻololi ʻia e ke ake. Hiki ke hoʻololi ʻo Quercetin i ka hana ʻana o kēia mau lāʻau a hoʻonui i ka hopena o nā hopena ʻaoʻao. ʻAʻohe mea i ʻike ʻia ma waena o ka quercetin a me nā meaʻai a i ʻole nā mea kanu ʻē aʻe a me nā mea hoʻohui.
He palekana anei ka quercetin no nā keiki?
ʻOiai ʻike maoli ʻia ka quercetin i nā meaʻai he nui a ua manaʻo ʻia he palekana no ka poʻe pākeke ma ka liʻiliʻi liʻiliʻi, aia nā noiʻi liʻiliʻi e pili ana i kona palekana a me ka pono no nā keiki, a ua ʻōlelo ʻia e akahele.
I ka manawa hea e lawe ai i ka quercetin?
Hiki iā ʻoe ke lawe i ka quercetin i kēlā me kēia manawa o ka lā. Eia nō naʻe, pono ʻoe e noʻonoʻo i ka lawe ʻana i ka wā ʻai no ka mea ʻo nā meaʻai i loaʻa i ka huaora C, bromelain, a me nā momona olakino hiki ke kōkua i kona ʻai ʻana. Eia hou, "makemake paha kekahi poʻe e lawe pū me nā meaʻai e hōʻemi i ka pilikia o ka ʻōpū," wahi a Kauka Ormond.